A new nomogram to predict pathologic outcome following radical prostatectomy

A new nomogram to predict pathologic outcome following radical prostatectomy

Author Crippa, Alexandre Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Dall'Oglio, Marcos Francisco Autor UNIFESP Google Scholar
Antunes, Alberto A. Autor UNIFESP Google Scholar
Leite, Kátia Ramos Moreira Autor UNIFESP Google Scholar
Nesrallah, Luciano J. Autor UNIFESP Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.
Keywords prostatic neoplasms
neoplasm staging
prostate-specific antigen
needle biopsy
Language English
Date 2006-04-01
Published in International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.
ISSN 1677-5538 (Sherpa/Romeo)
Publisher Sociedade Brasileira de Urologia
Extent 155-164
Origin http://dx.doi.org/10.1590/S1677-55382006000200005
Access rights Open access Open Access
Type Article
SciELO ID S1677-55382006000200005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2990

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