Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidation

Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidation

Author Franco, Maria do Carmo Pinho Autor UNIFESP Google Scholar
Kawamoto, Elisa M. Google Scholar
Gorjao, Renata Google Scholar
Rastelli, Viviani M. F. Google Scholar
Curi, Rui Google Scholar
Scavone, Cristoforo Google Scholar
Sawaya, Ana Lydia Autor UNIFESP Google Scholar
Fortes, Zuleica Bruno Google Scholar
Sesso, Ricardo de Castro Cintra Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Children born small for gestational age are known to be at increased risk for adult diseases such as hypertension, diabetes, and coronary heart disease. Oxidative stress is a common feature of these pathogenic conditions and can be the key link between size at birth and increased morbidity later in life. the purpose of this study was to analyze the parameters of lipoperoxidation and changes in antioxidant defense system as well as assess their relationship to birth weight. Concentrations of thiobarbituric-acid-reactive-substances and F-2-isoprostanes, total antioxidant status, and the activity of both superoxide dismutase and glutathione peroxidase were measured in 65 children (33 boys, 32 girls; ages 8-13 y). Thiobarbituric-acid-reactive-substances and F-2-isoprostane levels were significantly elevated in children born small for gestational age. Nevertheless, superoxide dismutase activity was significantly elevated in these children and the levels of both glutathione peroxidase activity and total antioxidant status were unchanged. Moreover, we found that systolic blood pressure was positively associated with thiobarbituric-acid-reactive-substances levels in race- and gender-adjusted models but not in a multivariable regression model. in conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation.
Language English
Date 2007-08-01
Published in Pediatric Research. Baltimore: Int Pediatric Research Foundation, Inc, v. 62, n. 2, p. 204-208, 2007.
ISSN 0031-3998 (Sherpa/Romeo, impact factor)
Publisher Int Pediatric Research Foundation, Inc
Extent 204-208
Origin http://dx.doi.org/10.1203/PDR.0b013e3180986d04
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000248339700019
URI http://repositorio.unifesp.br/handle/11600/29893

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