Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil

Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil

Author Leão-Filho, Gustavo Carneiro Google Scholar
Lopes, Edmundo P. A. Google Scholar
Ferraz, Alvaro Antonio B. Google Scholar
Moura, Izolda Google Scholar
Pernambuco, J. Ricardo Google Scholar
Reis, Cynthia Autor UNIFESP Google Scholar
Silva, Antônio Eduardo B. Autor UNIFESP Google Scholar
Ferraz, Maria Lucia G. Autor UNIFESP Google Scholar
Institution Universidade Federal de Pernambuco (UFPE)
Universidade Federal de São Paulo (UNIFESP)
Abstract The evidence of a higher incidence of hepatitis G virus (HGV) infection among patients with hepatocellular carcinoma (HCC) and the relatively high prevalence of patients with primary liver carcinoma without apparent risk factors in our country motivated the present study, the objective of which was to determine the frequency of HGV-ribonucleic acid (RNA) in a series of patients with HCC. the diagnosis of HCC was established based on a-fetoprotein levels (>400 ng/ml), a compatible image and/or biopsy of the hepatic nodules. Markers of hepatitis B virus (HBV) (HBsAg and anti-HBc), hepatitis C virus (HCV) (anti-HCV) and HGV (HGVRNA) were investigated using MEIA and RT-PCR (reverse transcriptase polymerase chain reaction). There were 32 patients evaluated, including 20 males (63%), with a mean age of 58 years. Twenty-eight (88%) patients were cirrhotic (Child-Pugh: A = 8 patients, B = 14, and C = 6) and 50% reported alcohol consumption. Serological hepatitis markers were detected in 26 (81%) patients, including HBV in 19 (59%), HCV in 12 (38%) and HGV in 9 (28%). Only one (3%) patient was positive for HGV alone. the prevalence of HGV in blood donors from the same region is 10%. the findings suggest that, despite the frequent detection of HGV markers in patients with HCC, isolated infection with this agent does not seem to be a relevant factor in the etiology of this carcinoma.
Keywords hepatitis G virus
hepatocellular carcinoma
hepatitis B virus
hepatitis C virus
Language English
Date 2007-08-01
Published in Japanese Journal of Clinical Oncology. Oxford: Oxford Univ Press, v. 37, n. 8, p. 632-636, 2007.
ISSN 0368-2811 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 632-636
Origin http://dx.doi.org/10.1093/jjco/hym063
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000250144200012
URI http://repositorio.unifesp.br/handle/11600/29882

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