Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats

Date
2007-06-01Author
Freitas, Raphael R. de A.
Lopes, Karen L.
Carillo, Bruno A.
Bergamaschi, Cassia T.
Carmona, Adriana K.
Casarini, Dulce E.
Furukawa, Luzia
Heimann, Joel C.
Campos, Ruy R.
Dolnikoff, Miriam S.
Type
ArtigoISSN
0895-7061Is part of
American Journal of HypertensionDOI
10.1016/j.amjhyper.2007.01.014Metadata
Show full item recordAbstract
Background: This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. in addition, angiotensin 1, 11, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue.Methods: Male Wistar rats were treated for 30 days with 20% sucrose solution (n = 21) or tap water (n = 19) and food ad libitum. Blood pressure, cardiac output, and total peripheral resistance were recorded at the end of the 30-day treatment period. Sympathetic and angiotensinergic systems were evaluated by acute hexamethonium and captopril administration; plasma and tissue (heart, kidney, and epididymal adipose tissue) angiotensins were measured by high-performance liquid chromatography; and angiotensin-converting enzyme activity was determined by continuous fluorescent assay. Plasma renin activity and plasma levels of insulin and leptin were evaluated by radioimmunoassay.Results: Chronic sucrose feeding was associated with increased blood pressure (BP) (129 +/- 1 v 102 +/- 3 mm Hg) and circulating insulin (171%) and leptin (356%) levels when compared with the control group. the sucrose group also showed a 27% higher renal sympathetic nervous activity. the depressor response to hexamethonium was similar in both groups, whereas captopril caused a more pronounced decrease in BP in the sucrose group than in controls (-40 +/- 2 v -11 +/- 2 mm Hg), possibly reflecting the higher plasma renin activity and plasma content of angiotensin II and renal angiotensin II in sucrose rats.Conclusions: These findings suggest a specific renal renin-angiotensin-sympathetic activation as a potential mechanism for the cardiovascular changes in response to chronic sucrose feeding. Am J Hypertens 2007;20: 692-698 (c) 2007 American Journal of Hypertension, Ltd.
Citation
American Journal of Hypertension. New York: Elsevier B.V., v. 20, n. 6, p. 692-698, 2007.Keywords
sympathetic nervous systemrenin-angiotensin system
hypertension
sucrose feeding
leptin
insulin
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