Involvement of the histaminergic system on appetitive learning and its interaction with haloperidol in goldfish

Involvement of the histaminergic system on appetitive learning and its interaction with haloperidol in goldfish

Author Medalha, Carla Christina Autor UNIFESP Google Scholar
Mattioli, Rosana Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Abstract This study investigated the actions of the histaminergic system on appetitive learning and memory, and its interaction with the dopaminergic system in goldfish. It consisted of nine sessions, in which fish were tested in a four-arm tank. On day 1, the animals were habituated for 10 min. On day 2, they were placed in one arm and had to find food at the left or the right arm. Time to begin feeding was recorded, and the procedure repeated for more 3 days (training phase). On training day 4, seven groups were injected with saline, seven with haloperidol (2.0 mg/kg) and one with DMSO solution before training and after feeding, three groups received saline, six chlorpheniramine (CPA) (1.0, 4.0 and 8.0 mg/kg), and Six L-histidine (LH) (25, 50 and 100 mg/kg). Saline groups were considered as control of CPA and LH treated groups and DMSO as control of haloperidol. A non-injected group was also included. Testing occurred after 24 h. A reversal procedure was conducted 24 h after testing and repeated for 3 days. the groups receiving CPA at 1.0 and 8.0 mg/kg and LH at 25, 50 and 100 mg/kg differed between Test and Reversal day 1. Pre-treatment with haloperidol plus 8.0 mg/kg of CPA and 25 and 50 mg/kg of LH reverted the treatment effect. However, in the groups treated with 1.0 mg/kg of CPA and 100 mg/kg of LH, the difference remained. This study confirmed the interaction between the histaminergic and the dopaminergic systems on memory process in goldfish. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords Haloperidol
Appetitive learning
Language English
Date 2007-05-17
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 418, n. 2, p. 195-200, 2007.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 195-200
Access rights Closed access
Type Article
Web of Science ID WOS:000246871600016

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