Acute action of aminophylline in patients with amyotrophic lateral sclerosis

Acute action of aminophylline in patients with amyotrophic lateral sclerosis

Author Berto, M. C. Google Scholar
Filha, S. C. Google Scholar
Camelier, A. Google Scholar
Rosa, F. W. Google Scholar
Oliveira, A. de Souza Bulle Google Scholar
Jardim, J. R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective - This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). the study was a randomized, double-blind, crossover against placebo. Materials and methods - Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P-Imax/P-Emax) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. Results - MVV (P < 0.02) and HS of the right and left hands (P = 0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P-Imax (r = 0.80; P < 0.05); between MVV and P-Imax post-aminophylline, respectively (r = 0.77; P < 0.05). Serum aminophylline levels ranged from 5.3 to 10.5 mu g/mL (mean 7.30). Conclusion - the acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
Keywords amyotrophic lateral sclerosis
muscle weakness
Language English
Date 2007-05-01
Published in Acta Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 115, n. 5, p. 301-305, 2007.
ISSN 0001-6314 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 301-305
Access rights Closed access
Type Article
Web of Science ID WOS:000246198900002

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