Slow inotropic response of intact left ventricle to sudden dilation critically depends on a myocardial dialysable factor
Tucci, Paulo J. F.
Faber, Cristiano N.
Santos, Leonardo dos
Antonio, Ednei L.
Is part ofClinical and Experimental Pharmacology and Physiology
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1. Slow inotropic response following a sudden myocardium stretch seems to be an autocrine/paracrine mechanism the basis of which is not yet completely defined.2. We compared the canine left ventricle (LV) response to sudden dilation when the LV was supported by the arterial blood of a support dog with when it was supported by an oxygenator + haemodialyser system.3. A slow inotropic response (SIR) after dilation was seen in all six hearts supported by the donor dog, attaining 87 +/- 6% of immediate increase, whereas a mere 10% SIR occurred in only one out of seven hearts maintained by the oxygenator + haemodialyser.4. These results indicate that SIR genesis involves one or more renewable components essential to the intracellular calcium gain elicited by stretch.
CitationClinical and Experimental Pharmacology and Physiology. Oxford: Blackwell Publishing, v. 34, n. 5-6, p. 515-516, 2007.
slow force response
sudden ventricular dilation
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