Morphological changes in the trigemino-rubral pathway in dystrophic (mdx) mice

Morphological changes in the trigemino-rubral pathway in dystrophic (mdx) mice

Author Pinto, Magali Luci Google Scholar
Tokunaga, Heloisa Helena Vieira Olyntho Google Scholar
Souccar, Caden Google Scholar
Schoorlemmer, Gerhardus Hermanus Maria Autor UNIFESP Google Scholar
Ribeiro da Silva Lapa, Rita de Cassia Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The lack of dystrophin that causes Duchenne muscle disease affects not only the muscles but also the central nervous system. Dystrophin-deficient mdx mice present changes in several brain fiber systems. We compared the projections from the trigeminal sensory nuclear complex to the red nucleus in control and mdx mice using retrograde tracers. Injection of 200 nL 2% fluorogold into the red nucleus caused labeling in the mesencephalic trigeminal nucleus, the principal sensory nucleus and the oral, interpolar, and caudal subnuclei of the spinal trigeminal nucleus in both control and mdx mice. Injection of latex microbeads labeled with rhodamine and fluorescein gave results similar to those seen with fluorogold. the number of labeled neurons in the trigeminal sensory nuclear complex was significantly reduced in mdx mice. in the oral subnucleus of the spinal trigeminal nucleus this reduction was 50%. These results indicate that the trigemino-rubral pathway is reduced in dystrophin-deficient mice. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords dystrophin
Duchenne muscle disease
mdx mouse
red nucleus
trigeminal sensory nuclear complex
Language English
Date 2007-04-12
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 416, n. 2, p. 175-179, 2007.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 175-179
Access rights Closed access
Type Article
Web of Science ID WOS:000246039100014

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