Molecular imaging in hereditary forms of parkinsonism

Molecular imaging in hereditary forms of parkinsonism

Author Shih, M. C. Google Scholar
Felicio, A. C. Google Scholar
Oliveira Godeiro-Junior, C. de Google Scholar
Carvalho Aguiar, P. de Google Scholar
Andrade, L. A. F. de Google Scholar
Ferraz, H. B. Google Scholar
Bressan, R. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract The development of in vivo molecular imaging to evaluate the dopamine (DA) system with positron-emission tomography and single photon emission computed tomography has been of key importance on monitoring in vivo nigrostriatal neuronal loss in Parkinson's disease (PD), mostly through assessments of pre- and post-synaptic DA receptors. the discoveries of genes related to hereditary forms of parkinsonism (PARK1, PARK2, PARK6, PARK7 and PARK8) have increased our understanding either of distinct subtypes of clinical expression in PD or its etiology. This article revises current data on molecular neuroimaging of genetic forms of parkinsonism comparing and contrasting its main features with the classical sporadic forms. Awareness of the spectrum variance in the genotype and its respective PD phenotype are useful to distinguish different pathophysiological mechanisms of PD.
Keywords genetics
molecular imaging
Parkinson's disease
positron-emission tomography
single photon emission computed tomography
Language English
Date 2007-04-01
Published in European Journal of Neurology. Oxford: Blackwell Publishing, v. 14, n. 4, p. 359-368, 2007.
ISSN 1351-5101 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 359-368
Origin http://dx.doi.org/10.1111/j.1468-1331.2007.01691.x
Access rights Closed access
Type Review
Web of Science ID WOS:000245155100008
URI http://repositorio.unifesp.br/handle/11600/29649

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