Blockade of neurotensin receptors during amphetamine discontinuation indicates individual variability

Blockade of neurotensin receptors during amphetamine discontinuation indicates individual variability

Author Costa, Fabiana G. Google Scholar
Frussa-Filho, Roberto Google Scholar
Canteras, Newton S. Google Scholar
Valera, Adriana G. Google Scholar
Felicio, Luciano F. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Psychostimulant-induced locomotor sensitization has been related to changes within the mesolimbic dopamine system and has been suggested to be useful to study mechanisms underlying drug craving. Neurotensin is a neuropeptide co-localized with dopamine in the mesolimbic system. the response to novelty has been suggested to be a predictor of enhanced vulnerability to behavioral sensitization. the effects of repeated treatment with the neurotensin antagonist SR48692 after amphetamine discontinuation were investigated in mice previously classified as high responders (HRs) or low responders (LRs) to novelty. Mice were repeatedly treated with 2.0 mg/kg amphetamine, every other day for I I days. During the first 7 days after amphetamine discontinuation, the animals received a daily injection of saline or 0.3 mg/kg SR48692. On the eighth day after amphetamine discontinuation all subjects received a 2.0 mg/kg amphetamine challenge injection. Then, mice were tested for an open field behavior and after 90 min, were sacrificed for Fos expression quantification in the nucleus accumbens. Both HRs and LRs expressed amphetamine-induced sensitized locomotor activation and increased expression of Fos protein. Treatment with SR48692 prevented behavioral sensitization and Fos protein expression enhancement in LRs but not in HRs mice. These data suggest that neurotensin plays a role in individual variability to amphetamine-induced sensitization. (c) 2007 Elsevier B.V. All rights reserved.
Keywords accumbens
limbic activation
locomotor activity
Language English
Date 2007-04-01
Published in Neuropeptides. Edinburgh: Churchill Livingstone, v. 41, n. 2, p. 83-91, 2007.
ISSN 0143-4179 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 83-91
Access rights Closed access
Type Article
Web of Science ID WOS:000245130300003

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