Pain hypersensitivity induced by paradoxical sleep deprivation is not due to altered binding to brain mu-opioid receptors

Nenhuma Miniatura disponível
Data
2007-03-28
Autores
Nascimento, Danielle da Cunha [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Hipólide, Débora Cristina [UNIFESP]
Nobrega, Jose N.
Tufik, Sergio [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Previous studies have established a relationship between sleep disruption and pain, and it has been suggested that hyperalgesia induced by paradoxical sleep deprivation (PSD) could be due to a reduction of opioidergic-neurotransmission in the brain. in the present study rats deprived of sleep for 96h as well as rats allowed to recover for 24h after PSD and normal controls received vehicle or morphine (2.5, 5 and 10mg/kg, i.p.) and were tested on a hot plate 1 h later. Quantitative receptor autoradiography was used to map alterations in binding to brain mu-opioid receptors in separate groups. Results demonstrated that PSD induced a significant reduction in thermal pain threshold, as measured by paw withdrawal latencies. This effect did not return to baseline control values after 24h of sleep recovery. the usual analgesic effect of morphine was observed in the control group but not in PSD or rebound groups except at the highest dose (10mg/kg). Binding of [H-3]DAMGO to mu sites did not differ significantly among the three groups in any of the 33 brain regions examined. These results do not exclude the participation of the opioid system in PSD-induced pain hypersensitivity since sleep-deprived rats were clearly resistant to morphine. However, the fact no changes were seen in [H-3]DAMGO binding indicates that mechanisms other than altered mu-opioid binding must be sought to explain the phenomenon. (c) 2007 Published by Elsevier B.V.
Descrição
Citação
Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 178, n. 2, p. 216-220, 2007.
Coleções