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dc.contributor.authorCarregaro, Adriano B.
dc.contributor.authorLuna, Stelio P. L.
dc.contributor.authorMataqueiro, Maria Isabel
dc.contributor.authorQueiroz-Neto, Antonio de
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 68, n. 3, p. 246-250, 2007.
dc.description.abstractObjective-To investigate spontaneous locomotor activity (SLA) and antinociceptive effects of buprenorphine in horses.Animals-6 healthy adult horses.Procedures-Horses received each of 3 treatments (10 mL of saline [0.9% NaCl] solution, 5 mu g of buprenorphine/kg, or 10 mu g of buprenorphine/kg). Treatments were administered IV Order of treatments was randomized, and there was a 10-day interval between subsequent treatments. Spontaneous locomotor activity was investigated in a behavioral box by use of infrared photoelectric sensors connected to a computer, which detected movement of each horse. Antinociceptive effect was investigated by hoof-withdrawal reflex latency (HWRL) and skin-twitching reflex latency (STBL) after painful stimulation with a heat lamp.Results-Moderate excitement was observed in all horses from 5 to 10 minutes after the administration of both dosages of buprenorphine. the SLA increased significantly for 6 and 14 hours after IV administration of 5 and 10 mu g of buprenorphine/kg, respectively. Values for HWRL increased significantly only at 30 minutes after injection of 5 mu g of buprenorphine/kg, whereas STRL and HWRL each increased significantly from 1 to 6 hours (except at 2 and 4 hours) and 11 hours, respectively, after injection of 10 mu g of buprenorphine/kg.Conclusions and Clinical Relevance-IV injection of buprenorphine caused a dose-dependent increase in SLA, but only the dose of 10 mu g/kg induced analgesia on the basis of results for the experimental method used.en
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.rightsAcesso restrito
dc.titleEffects of buprenorphine on nociception and spontaneous locomotor activity in horsesen
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agrarias & Vet, BR-14884900 Jaboticabal, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.sourceWeb of Science

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