Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection
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Data
2007-03-01
Autores
Aggio, Fabio Bom [UNIFESP]
Farah, M. E.
Melo, G. B. de
d'Azevedo, P. A.
Pignatri, A. C. C.
Hofling-Lima, A. L.
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Artigo
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Purpose: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.Methods: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later. Vitreous samples were obtained, followed by the injection of vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml. Pulsed-field gel electrophoresis (PFGE) was used to determine whether the isolated microorganisms were the same.Results: Coagulase-negative staphylococci were identified and isolated from the vitreous specimen of both patients. PFGE revealed different patterns of banding, excluding that interpatient contamination occured.Conclusions: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.
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Eye. London: Nature Publishing Group, v. 21, n. 3, p. 408-409, 2007.