The effects of ruthenium tetraammine compounds on vascular smooth muscle

The effects of ruthenium tetraammine compounds on vascular smooth muscle

Author Zanichelli, P. G. Google Scholar
Estrela, H. F. G. Google Scholar
Spadari-Bratfisch, Regina Celia Autor UNIFESP Google Scholar
Grassi-Kassisse, D. M. Google Scholar
Franco, D. W. Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The time course of the relaxation effect induced by a single dose (3 x 10(-6) mol/L) of trans-[Ru(NH(3))(4)L(NO)](3+) (L = nic, 4-pic, py, imN, P(OEt)(3), SO(3)(2-), NH(3), and pz) species and sodium nitroprusside (4 x 10(-9) mol/L) was studied in aortic rings without endothelium and pre-contracted with noradrenaline (1 x 10(-6) mol/L). All the compounds induced a relaxing effect in the aortic rings, but the intensity and time of relaxation were different. Only the species where L = py, 4-pic, and P(OEt)(3) were able to induce 100% (99-100%) of the relaxing effect during the assay. trans-[Ru(NH(3))(4)(L)(NO)](3+) (L = SO(3)(2-) and NH(3)) showed the lowest relaxing effect (36 and 37%, respectively) when compared with the other compounds. Relationship was observed between the time corresponding to half of the maximum relaxation intensity observed and, respectively, k(-NO), E([Ru(NO)])(/[Ru(NO)])(0')(3+)(2+') in trans-[Ru(NH(3))(4)(L)(NO)](3+) species and E(Ru(III)/Ru(II))(0') in trans- [Ru(NH(3))(4)(L)(H(2)O)](3+) ions. These relationships strongly suggested that the NO liberation from the reduced nitrosyl complexes was responsible for the observed relaxation. (c) 2006 Elsevier Inc. All rights reserved.
Keywords Ruthenium nitrosyl
NO donors
Vasodilator activity
Language English
Date 2007-03-01
Published in Nitric Oxide-biology and Chemistry. San Diego: Academic Press Inc Elsevier Science, v. 16, n. 2, p. 189-196, 2007.
ISSN 1089-8603 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 189-196
Access rights Closed access
Type Article
Web of Science ID WOS:000244077900002

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