Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkin's disease

Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkin's disease

Author Pinheiro, Gevina Silva Autor UNIFESP Google Scholar
Silva, Maria Regina Regis Autor UNIFESP Google Scholar
Rodrigues, Celso Arrais Autor UNIFESP Google Scholar
Kerbauy, Jose Autor UNIFESP Google Scholar
Oliveira, José Salvador Rodrigues de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract CONTEXT and OBJECTIVE: Tumor cells in Hodgkin's disease (HD) express cell proliferation markers that are evaluated according to the oncogenes involved or the expression of their proteins. Correlations between the protein expression grade and clinical data are now important for disease prognosis.DESIGN and SETTING: This was a retrospective analysis on proliferating cell nuclear antigen (PCNA), p53 and MDM2 (murine double minute-2) expression using immunohistochemistry, on formalin-fixed, paraffin-embedded tissues from diagnostic biopsies on 51 patients with HID. the study was conducted at the Division of Hematology and Transfusion Medicine, Hospital São Paulo, Universidade Federal de São Paulo.METHODS: Antigen expression was evaluated as the proportions of positive Hodgkin and Reed-Sternberg (HRS) cells and reactive lymphocytes (L), which were compared using Spearman correlation coefficients. the Friedman test was used for comparisons between the markers. the Pearson test was used to investigate associations between marker expression and clinical and laboratory parameters, marrow involvement, complete remission (CR) and overall survival (OS) rates.RESULTS: There was overexpression of antigen proteins in HRS, in relation to L (p < 0.001). in HRS, MDM2 was higher than p53 and PCNA (p < 0.003), while the latter two were equivalent. in L, p53 was lower than MDM2 and PCNA (p < 0.001), while the latter two were equivalent. There was no relationship between protein expression and clinical and laboratory variables or outcome.CONCLUSIONS: PCNA, p53 and MDM2 are tumor markers for HID, but showed no clinical or prognostic significance in our analysis.
Keywords proliferating cell nuclear antigen
p53 genes
proto-oncogene proteins c-mdm2
Hodgkin disease
immunohistochemistry
Language English
Date 2007-03-01
Published in São Paulo Medical Journal. São Paulo: Associacao Paulista Medicina, v. 125, n. 2, p. 77-84, 2007.
ISSN 1516-3180 (Sherpa/Romeo, impact factor)
Publisher Associacao Paulista Medicina
Extent 77-84
Origin http://dx.doi.org/10.1590/S1516-31802007000200003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258506900003
SciELO ID S1516-31802007000200003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/29527

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