Intravitreal bevacizumab for exudative age-related macular degeneration after multiple treatments

Intravitreal bevacizumab for exudative age-related macular degeneration after multiple treatments

Author Aggio, Fabio Bom Google Scholar
Farah, Michel Eid Google Scholar
Silva, Wagner Camilo Google Scholar
Melo, Gustavo Barreto Google Scholar
Institution Alameda Jau
Universidade Federal de São Paulo (UNIFESP)
Abstract Photodynamic therapy with verteporfin (PDT) significantly reduces the risk of vision loss in patients with exudative age-related macular degeneration (AMD). Indocyanine green-mediated photothrombosis (IMP) and transpupillary thermotherapy (TTT) may also be beneficial for selective cases of exudative AMD. However, a substantial subset of patients responds poorly to these treatments. Intravitreal bevacizumab (IVB) has been recently used in the treatment of exudative AMD, showing both visual and anatomic improvement in the majority of cases.This interventional retrospective case series reports the effects of IVB in 17 eyes with subfoveal neovascular AMD that had undergone repeated PDT (combined or not with triamcinolone acetonide) or PDT followed by either IMP or TTT with poor results. the main outcome measures were visual acuity and tomographic signs of intra/subretinal fluid, as well as central retinal thickness.Most patients received a single IVB injection. the mean follow-up was 4.47 months. the mean logMAR visual acuity changed from 1.17 +/- 0.40 to 1.06 +/- 0.44 (P=0.17). the mean central retinal thickness decreased from 404.05 +/- 245.26 to 280.23 +/- 143.14 mu m (P=0.032). At the end of the study, lack of tomographic signs of intra/subretinal fluid was noted in four (23.5%) eyes. No ocular or systemic side effects were identified.Short-term results with IVB for the treatment of exudative AMD have been promising. However, the chronic retinal and pigment epithelium changes frequently present in eyes that underwent multiple previous treatments may limit complete visual recovery. To our knowledge, this is the first report on the use of IVB for this particular group of AMD patients.
Keywords VEGF
intravitreal bevacizumab
age-related macular degeneration
photodynamic therapy
Language English
Date 2007-02-01
Published in Graefes Archive for Clinical and Experimental Ophthalmology. New York: Springer, v. 245, n. 2, p. 215-220, 2007.
ISSN 0721-832X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 215-220
Access rights Closed access
Type Article
Web of Science ID WOS:000244295200005

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