Effects of 3-nitropropionic acid administration on memory and hippocampal lipid peroxidation in sleep-deprived mice

Effects of 3-nitropropionic acid administration on memory and hippocampal lipid peroxidation in sleep-deprived mice

Author Silva, Regina H. Google Scholar
Abilio, Vanessa C. Google Scholar
Kameda, Sonia R. Google Scholar
Takatsu-Coleman, Andre L. Google Scholar
Carvalho, Rita C. Google Scholar
Ribeiro, Rosana de A. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Google Scholar
Institution UFRN
Universidade Federal de São Paulo (UNIFESP)
Abstract Numerous studies have described memory deficits following sleep deprivation. There is also evidence that the absence of sleep increases brain oxidative stress. the present study investigates the effects of a pro-oxidant agent-3-nitropropionic acid (3-NP)-on hippocampal oxidative stress and passive avoidance performance of sleep-deprived mice. Mice were repeatedly treated i.p. with saline or 5 or 15 mg/kg 3-NP and sleep-deprived for 24 h by the multiple platform method-groups of 4-5 animals placed in water tanks, containing 12 platforms (3 cm in diameter) surrounded by water up to 1 cm beneath the surface or kept in their home cage (control groups). the results showed that: (1) neither a 24 h sleep deprivation period nor 3-NP repeated treatment alone were able to induce memory deficits and increased hippocampal lipid peroxidation; (2) this same protocol of sleep deprivation, combined with 15 mg/kg 3-NP repeated treatment, induced memory deficits and an increase in hippocampal lipid peroxidation. the results support the involvement of hippocampal oxidative stress in the memory deficits induced by sleep deprivation and the hypothesis that normal sleep would prevent oxidative stress. (c) 2006 Elsevier Inc. All rights reserved.
Keywords 3-nitroptropionic acid
avoidance learning
memory
oxidative stress
sleep deprivation
Language English
Date 2007-01-30
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 31, n. 1, p. 65-70, 2007.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 65-70
Origin http://dx.doi.org/10.1016/j.pnpbp.2006.06.019
Access rights Closed access
Type Review
Web of Science ID WOS:000243738000008
URI http://repositorio.unifesp.br/handle/11600/29467

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