Hepatitis C in chronic kidney disease: Predialysis patients present more severe histological liver injury than hemodialysis patients?

Hepatitis C in chronic kidney disease: Predialysis patients present more severe histological liver injury than hemodialysis patients?

Author Lemos, Lara B. Google Scholar
Perez, Renata M. Google Scholar
Lemos, Marcelo M. Google Scholar
Lanzoni, Valeria P. Google Scholar
Draibe, Sergio A. Google Scholar
Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Silva, Antonio Eduardo B. Google Scholar
Ferraz, Maria Lucia G. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Background: the characteristics of hepatitis C virus (HCV) infection in predialysis patients are poorly understood and they could be different from hemodialysis patients. Aims: To evaluate the demographics, laboratory and histological characteristics of chronic HCV infection in predialysis patients and to compare them with those observed in hemodialysis patients. Methods: Thirty-nine predialysis patients with chronic HCV infection were compared to HCV-infected hemodialysis patients (ratio of 1: 3) in terms of demographics, laboratory and histological characteristics. the fibrosis progression rate (FPR) was calculated as the ratio between fibrosis stage and duration of infection. Results: Predialysis patients were older (57 8 10 vs. 45 8 12 years; p < 0.001), presented a higher proportion of elevated alanine aminotransferase (71.8 vs. 41.0%; p = 0.001) and aspartate aminotransferase (64.1 vs. 26.5%; p < 0.001), a higher proportion of interface hepatitis (66.7 vs. 47%; p = 0.033) and more advanced fibrosis (71.8 vs. 16.2%; p = 0.001). Among patients with estimated duration of infection, predialysis patients presented a longer duration of infection (22 vs. 6 years; p < 0.001) and no difference in FPR was observed between groups (p = 0.692). Conclusion: Although predialysis patients with HCV infection present more severe histological injury than hemodialysis patients, this finding probably reflects a longer duration of infection with no evidence supporting that hepatitis C presents a more aggressive course in this group. Copyright (c) 2007 S. Karger AG, Basel
Keywords hepatitis C virus
chronic kidney disease
alanine aminotransferase
Language English
Date 2007-01-01
Published in American Journal of Nephrology. Basel: Karger, v. 27, n. 2, p. 191-196, 2007.
ISSN 0250-8095 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 191-196
Origin http://dx.doi.org/10.1159/000100892
Access rights Closed access
Type Article
Web of Science ID WOS:000245138400012
URI http://repositorio.unifesp.br/handle/11600/29438

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