Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

Author Iores-Marcal, Ligia M. Autor UNIFESP Google Scholar
Viel, Tania A. Google Scholar
Buck, Hudson Sousa Google Scholar
Nunes, Viviane A. Autor UNIFESP Google Scholar
Gozzo, Andrezza Justino Autor UNIFESP Google Scholar
Cruz-Silva, Ilana Autor UNIFESP Google Scholar
Miranda, Antonio Autor UNIFESP Google Scholar
Shimamoto, Kazuaki Google Scholar
Ura, Nobuyuki Google Scholar
Araujo, Mariana S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Ciencias Med Santa Casa São Paulo
Sapporo Med Univ
Abstract The kallikrein-kinin system is involved in a variety of physiological and pathological processes. Components of this system, identified in rat and human brains, can be altered in neurodegenerative processes such as Alzheimer's disease. Here, we studied kinin release and its inactivation in rats submitted to chronic cerebroventricular infusion of beta-amyloid (A beta) peptide. Neurodegeneration was confirmed by histological analysis of brain samples. in cerebrospinal fluid of animals infused with A beta, bradykinin concentration was increased, as determined by radioimmunoassay. However, in the brain of A beta group, we only detected the tripeptide Arg-Pro-Pro, purified by reversed-phase chromatography and characterized by liquid chromatography-electrospray ionization mass spectrometry. This fragment of bradykinin indicated the possible participation of kinin-processing enzymes in the brain such as a prolyl oligopeptidase. (c) 2006 Elsevier Inc. All rights reserved.
Keywords beta-amyloid
kallikrein-kinin system
Language English
Date 2006-12-01
Published in Peptides. New York: Elsevier B.V., v. 27, n. 12, p. 3363-3369, 2006.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 3363-3369
Access rights Closed access
Type Article
Web of Science ID WOS:000242821300042

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