Revisiting the addition reaction of TeCl4 to alkynes: the crystal structure and docking studies of 1-chloro-2-trichlorotelluro-3-phenyl-propen-2-ol

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2006-11-15
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Cunha, Rodrigo L. O. R.
Zukerman-Schpector, Julio
Caracelli, I.
Comasseto, Joao V.
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Tellurium tetrachloride adds to alkynes via two pathways: a concerted syn addition, that yields Z-tri- and tetra-substituted alkenes or by an anti addition that yields E-alkenes. the mechanistic aspects of these divergent pathways have been reevaluated at the light of crystallographic data. the molecules, of the title compound, in the crystal, are associated in a helical fashion with a Te...Te pitch of 6.3492(6) angstrom. As it exhibits inhibitory activity for cathepsin B and in order to gain more insight of the inhibition mechanism, a docking study was undertaken providing insight on why organic telluranes are more efficient inhibitors than inorganic ones as AS-101. (c) 2006 Elsevier B.V. All rights reserved.
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Journal of Organometallic Chemistry. Lausanne: Elsevier Science Sa, v. 691, n. 23, p. 4807-4815, 2006.