Effects of medial amygdala inactivation on a panic-related behavior

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dc.contributor.author Herdade, Karina Costa Paes
dc.contributor.author Strauss, Christiana Villela de Andrade
dc.contributor.author Zangrossi Junior, Helio
dc.contributor.author Viana, Milena de Barros [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:29Z
dc.date.available 2016-01-24T12:41:29Z
dc.date.issued 2006-09-25
dc.identifier https://dx.doi.org/10.1016/j.bbr.2006.05.021
dc.identifier.citation Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 172, n. 2, p. 316-323, 2006.
dc.identifier.issn 0166-4328
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/29159
dc.description.abstract In the last years, the role played by the medial nucleus of the amygdala (MeA) in the modulation of fear- and anxiety-related behaviors has been increasingly investigated. This nucleus plays an important role in the processing of predator odor-induced defensive reactions, i.e. freezing and risk-assessment behaviors. Immunohistochemical evidence also indicates that the MeA may be involved in the regulation of escape, a defensive behavior related to panic attacks. in this study, we further addressed this question by investigating the effects of the reversible inactivation of the nucleus on escape behavior generated in male Wistar rats by two different aversive stimuli, electrical stimulation of the dorsal periaqueductal gray matter (dPAG) and exposure to one of the open arms of the elevated T-maze. Results showed that intra-MeA administration of either the reversible sodium channel blocker lidocaine (34 nmol/0.2 mu l) or the GABA(A) receptor agonist muscimol (0.22 nmol/0.2 mu l) raised the threshold of aversive electrical stimulation, increasing the amount of current that applied to the dPAG evokes escape, an antiaversive effect. Local microinjection of muscimol (0.22 nmol/0.2 mu l) inhibited escape behavior in the elevated T-maze, also suggesting an antiaversive effect. in this latter test, muscimol did not affect inhibitory avoidance, a behavior associated with generalized anxiety disorder. Muscimol effect in the elevated T-maze was independent of changes in general exploratory activity as measured in an open-field. Taken together, our data corroborate previous evidences suggesting that the MeA is involved in the modulation of escape. Dysfunction of this regulatory mechanism may be of relevance in the genesis/maintenance of panic disorder. (c) 2006 Elsevier B.V. All rights reserved. en
dc.format.extent 316-323
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Behavioural Brain Research
dc.rights Acesso restrito
dc.subject Medial amygdala en
dc.subject Anxiety en
dc.subject Fear en
dc.subject Escape en
dc.subject Generalized anxiety en
dc.subject Panic disorder en
dc.title Effects of medial amygdala inactivation on a panic-related behavior en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Pontificia Univ Catolica
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, Brazil
dc.description.affiliation Univ São Paulo, FFCLRP, Lab Psicofarmacol, BR-14040901 Ribeirao Preto, Brazil
dc.description.affiliation Univ São Paulo, FMRP, Dept Farmacol, BR-14040901 Ribeirao Preto, Brazil
dc.description.affiliation Pontificia Univ Catolica, Fac Psicol, Dept Psicol Desenvolvimento, BR-05014901 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, Brazil
dc.identifier.doi 10.1016/j.bbr.2006.05.021
dc.description.source Web of Science
dc.identifier.wos WOS:000240241300018



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