Performance of the DNA-Citoliq liquid-based cytology system compared with conventional smears

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2006-04-01
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Alves, VAF
Castelo, A.
Filho, A. L.
Vianna, M. R.
Taromaru, E.
Namiyama, G.
Lorincz, A.
Dores, GBD
DNA-Citoliq Working Grp
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Objective: To evaluate the performance of a new, manual, simplified liquid-based system, DNA-Citoliq (Digene Brasil), employed under routine conditions as compared to conventional smears collected from six collaborating private laboratories.Methods: A panel of cytopathologists, who served as the gold standard diagnosis, adjudicated discordant opinions.Results: of 3206 pairs of slides considered valid for comparison, there were 3008 in full agreement (93.8%), 112 (3.5%) with one diagnostic category discrepancies, and 86 (2.7%) discordant cases. Among the 288 borderline+ by either method, DNA-Citoliq detected abnormalities in 243 (84.4%), and conventional smears (CS) detected abnormalities in 178 (61.8%) (McNemar test, P < 0.000), a 36.5% increased detection of borderline+ cases.Conclusions: for mild dyskaryosis, DNA-Citoliq detected 176 cases and CS 125 cases (McNemar test, P < 0.000); and for moderate+severe dyskaryosis 66 versus 32 cases respectively (McNemar test, P < 0.000).
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Cytopathology. Oxford: Blackwell Publishing, v. 17, n. 2, p. 86-93, 2006.
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