Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

Author Fogaca, A. C. Google Scholar
Almeida, I. C. Google Scholar
Eberlin, M. N. Google Scholar
Tanaka, A. S. Google Scholar
Bulet, P. Google Scholar
Daffre, S. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Atheris Labs
Abstract The presence of an effective immune response in the hemocoel of arthropods is essential for survival as it prevents the invasion of pathogens throughout the animal body. Antimicrobial peptides (AMPs) play an important role in this response by rapidly killing invading microorganisms. in this study, a novel cysteine-rich AMP has been isolated and characterized from the hemocytes of the cattle tick, Boophilus microplus. in addition to growth inhibition of Escherichia coli and Micrococcus luteus, the newly described AMP, designated ixodidin (derived from the Family Ixodidae), was found to exert proteolytic inhibitory activity against two exogenous serine proteinases, elastase and chymotrypsin. This is the first report of a molecule of an arachnid that has been shown to inhibit bacterial growth and proteinase activity. (c) 2005 Elsevier Inc. All rights reserved.
Keywords antimicrobial peptide
serine proteinase inhibitor
immune system
hemocyte
tick
Language English
Date 2006-04-01
Published in Peptides. New York: Elsevier B.V., v. 27, n. 4, p. 667-674, 2006.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 667-674
Origin http://dx.doi.org/10.1016/j.peptides.2005.07.013
Access rights Closed access
Type Article
Web of Science ID WOS:000237047000009
URI http://repositorio.unifesp.br/handle/11600/28823

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