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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorAntunes, Isabela B. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.identifier.citationHormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 49, n. 2, p. 173-180, 2006.
dc.description.abstractThis study examined the effects of cocaine on genital reflexes in paradoxical sleep-deprived (PSD) male rats of five strains since it has been demonstrated that this drug enhances genital reflexes in Wistar PSD rats. At the end of a 4-day period of PSD or at the equivalent time-point to control animals, cocaine or saline was acutely administered to the animals and penile erection (PE) and ejaculation (EJ) were quantified. Results indicated that PSD induced genital reflexes in all strains, and cocaine potentiated these behaviors in Wistar and Long-Evans rats. Wistar PSD rats injected with cocaine performed significantly more PE than all the other PSD + cocaine strains. the number of Wistar and Long-Evans PSD + cocaine ejaculating was significantly higher than the respective PSD + saline and control, whereas a tendency of increase was seen in relation to other groups. Wistar PSD + cocaine rats showed the highest EJ frequency compared to F344, Sprague-Dawley and Wistar-Kyoto strains, and the Long-Evans displayed more EJ than Sprague-Dawley and Wistar-Kyoto. Analysis of testosterone concentrations revealed that after sleep deprivation, Wistar, Long-Evans, and F344 rats showed significantly lower testosterone concentrations than control rats. in F344, Sprague-Dawley and Wistar-Kyoto controls rats, testosterone was significantly lower than in the control Wistar and Long-Evans. Progesterone concentrations were significantly hither in Wistar and Long-Evans PSD rats than in respective control groups. in the other strains, this hormone was significantly lower compared to the Wistar and Long-Evans PSD. This study demonstrates that genital reflexes are differently influenced by PSD associated to cocaine in five rat strains. (c) 2005 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherElsevier B.V.
dc.relation.ispartofHormones and Behavior
dc.rightsAcesso restrito
dc.subjectSleep deprivationen
dc.subjectGenital reflexesen
dc.subjectSexual behavioren
dc.subjectStrain differencesen
dc.titleEffects of paradoxical sleep deprivation on genital reflexes in five rat strainsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, EPM, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, EPM, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 01/04329-0
dc.description.sponsorshipIDFAPESP/CEPID: 98/14303-3
dc.description.sourceWeb of Science

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