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dc.contributor.authorKaari, Cristina [UNIFESP]
dc.contributor.authorHaidar, Mauro Abi [UNIFESP]
dc.contributor.authorSoares Junior, Jose Maria [UNIFESP]
dc.contributor.authorNunes, Marcia Gaspar [UNIFESP]
dc.contributor.authorQuadros, Luis Gerk de Azevedo [UNIFESP]
dc.contributor.authorKemp, Claudio [UNIFESP]
dc.contributor.authorStavale, Joao Norberto
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.date.accessioned2016-01-24T12:40:54Z
dc.date.available2016-01-24T12:40:54Z
dc.date.issued2006-01-10
dc.identifierhttp://dx.doi.org/10.1016/j.maturitas.2005.02.009
dc.identifier.citationMaturitas. Clare: Elsevier B.V., v. 53, n. 1, p. 49-58, 2006.
dc.identifier.issn0378-5122
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28690
dc.description.abstractObjective: the aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.Methods: It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two treatment groups: isoflavone (n = 40): 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone (60 mg twice a day), or estrogen (n = 39): one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg (placebo).Results: After treatment, there was a decrease in the symptomatology in both estrogen and isoflavone groups. There was a significant decrease in vaginal pH, an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group, but no differences were observed in the isoflavone group for these variables.Conclusions: We concluded that the daily standardized soy extract with 120 mg isoflavones' effect on symptoms was similar to that from estrogen. Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en
dc.format.extent49-58
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaturitas
dc.rightsAcesso aberto
dc.subjectisoflavoneen
dc.subjectpostmenopausal womenen
dc.subjecthormone therapyen
dc.titleRandomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot studyen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04513031 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04513031 São Paulo, Brazil
dc.identifier.doi10.1016/j.maturitas.2005.02.009
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000234640100007


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