Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study

Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study

Author Kaari, Cristina Autor UNIFESP Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Soares Junior, Jose Maria Autor UNIFESP Google Scholar
Nunes, Marcia Gaspar Autor UNIFESP Google Scholar
Quadros, Luis Gerk de Azevedo Autor UNIFESP Google Scholar
Kemp, Claudio Autor UNIFESP Google Scholar
Stavale, Joao Norberto Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.Methods: It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two treatment groups: isoflavone (n = 40): 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone (60 mg twice a day), or estrogen (n = 39): one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg (placebo).Results: After treatment, there was a decrease in the symptomatology in both estrogen and isoflavone groups. There was a significant decrease in vaginal pH, an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group, but no differences were observed in the isoflavone group for these variables.Conclusions: We concluded that the daily standardized soy extract with 120 mg isoflavones' effect on symptoms was similar to that from estrogen. Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords isoflavone
postmenopausal women
hormone therapy
Language English
Date 2006-01-10
Published in Maturitas. Clare: Elsevier B.V., v. 53, n. 1, p. 49-58, 2006.
ISSN 0378-5122 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 49-58
Origin http://dx.doi.org/10.1016/j.maturitas.2005.02.009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000234640100007
URI http://repositorio.unifesp.br/handle/11600/28690

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