Effects of progesterone on sleep: A possible pharmacological treatment for sleep-breathing disorders?

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Data
2006-01-01
Autores
Andersen, Monica Levy [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Antunes, I. B.
Tufik, Sergio [UNIFESP]
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Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. the literature also contains a substantial amount of data on the effect of apnea in women with obesity-hypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.
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Current Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 13, n. 29, p. 3575-3582, 2006.