Urinary hyaluronan as a marker for the presence of residual transitional cell carcinoma of the urinary bladder

Urinary hyaluronan as a marker for the presence of residual transitional cell carcinoma of the urinary bladder

Author Passerotti, C. C. Google Scholar
Bonfim, A. Google Scholar
Martins, JRM Google Scholar
Dall'Oglio, M. F. Google Scholar
Sampaio, L. O. Google Scholar
Mendes, A. Google Scholar
Ortiz, V Google Scholar
Srougi, M. Google Scholar
Dietrich, C. P. Google Scholar
Nader, H. B. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the purpose of this report is to evaluate the value of urinary hyaluronan (HA) as a maker of residual transitional cell carcinoma (TCC).Patients and methods: Urine samples were collected from 83 patients hospitalized for transurethral resection (TUR). Patient ages ranged from 36 to 86 years. Samples were taken both before and after surgery. HA analysis was performed using an '' ELISA-like '' fluorometric assay.Results: Patients were divided into two groups: a control group whose previous diagnosis was negative for tumors (n = 22) and another with positive diagnosis for tumors (n = 61) which was further sub-divided into with and without residual tumor. After the second procedure 47 individuals did not display residual tumor, whereas 14 (23%) did. the average HA in the control group was 8.3 mu g/L pre- and 7.1 post-operatively, hence, no change occurred (p = 0.471). in the group with TCC patients, the HA dropped from 885.5 mu g/L to 215.3 mu g/L with residual tumors and from 234.3 mu g/L to 11.2 mu g/L for those without residual tumor. Using a cut-off value of 20 mu g/L, the sensitivity to detect residual tumor is 92.9% and specificity is 83%.Conclusion: HA in addition to being one of the best markers for the initial evaluation of bladder carcinoma can be used to determine the presence of a residual tumor. This is associated with poor prognosis. (c) 2005 Elsevier B.V. All rights reserved.
Keywords urinary hyaluronan
transitional cell carcinoma
transurethral resection
Language English
Date 2006-01-01
Published in European Urology. Amsterdam: Elsevier B.V., v. 49, n. 1, p. 71-75, 2006.
ISSN 0302-2838 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 71-75
Origin http://dx.doi.org/10.1016/j.eururo.2005.09.015
Access rights Closed access
Type Article
Web of Science ID WOS:000234576900012
URI http://repositorio.unifesp.br/handle/11600/28643

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