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dc.contributor.authorTeles, H. L.
dc.contributor.authorHemerly, Jefferson Pessoa [UNIFESP]
dc.contributor.authorPauletti, P. M.
dc.contributor.authorPandolfi, JRC
dc.contributor.authorAraujo, A. R.
dc.contributor.authorValentini, SR
dc.contributor.authorYoung, MCM
dc.contributor.authorBolzani, V. D.
dc.contributor.authorSilva, DHS
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
dc.description.abstractAn ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells.en
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsAcesso restrito
dc.subjectStyrax camporumen
dc.subjectcytotoxic lignansen
dc.subjectMTT assayen
dc.titleCytotoxic lignans from the stems of Styrax camporum (Styracaceae)en
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Bot
dc.description.affiliationUNESP, Inst Quim, BR-14800900 Araraquara, Brazil
dc.description.affiliationUNIFESP, Escola Paulista Med, BR-14801902 Araraquara, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, Brazil
dc.description.affiliationInst Bot, Secao Fisiol & Bioquim Plantas, BR-01061970 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, EPM
dc.description.sourceWeb of Science

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