Developmental abnormalities in striatum in young bipolar patients: a preliminary study

Developmental abnormalities in striatum in young bipolar patients: a preliminary study

Author Sanches, M. Google Scholar
Roberts, R. L. Google Scholar
Sassi, R. B. Google Scholar
Axelson, D. Google Scholar
Nicoletti, M. Google Scholar
Brambilla, P. Google Scholar
Hatch, J. P. Google Scholar
Keshavan, M. S. Google Scholar
Ryan, N. D. Google Scholar
Birmaher, B. Google Scholar
Soares, J. C. Google Scholar
Institution Univ Texas
S Texas Vet Hlth Care Syst
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Pittsburgh
Univ Udine
Abstract Objectives: Anatomical abnormalities in the basal ganglia of adult mood disorder patients have been reported. To investigate whether these abnormalities are present early in illness course, we compared the volume of striatal structures in young bipolar patients and healthy controls.Methods: Brain magnetic resonance images of 15 children and adolescents who met DSM-IV criteria for bipolar disorders and 21 healthy controls were obtained. Measurements were performed manually, by trained evaluators, who were blind to subjects' diagnosis. the volumes of caudate and putamen were compared in patients and controls.Results: the volumes of striatal structures were not significantly different in patients and controls (ANCOVA, p > 0.05). However, we found a significant inverse relationship between age and the volumes of left caudate (r = -0.72, p < 0.01), right caudate (r = -0.66, p = 0.02) and left putamen (r = -0.71, p = 0.01) in bipolar patients, not present in healthy controls.Conclusions: Abnormalities in striatal development may be involved in the pathophysiology of bipolar disorder.
Keywords affective disorders
basal ganglia
magnetic resonance imaging
mood disorders
Language English
Date 2005-04-01
Published in Bipolar Disorders. Copenhagen: Blackwell Munksgaard, v. 7, n. 2, p. 153-158, 2005.
ISSN 1398-5647 (Sherpa/Romeo, impact factor)
Publisher Blackwell Munksgaard
Extent 153-158
Access rights Closed access
Type Article
Web of Science ID WOS:000227589400007

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