Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats

Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats

Author Wohlers, Marta Autor UNIFESP Google Scholar
Xavier, Roberta Araújo Navarro Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Silveira, Vera Lucia Flor Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We have previously demonstrated that both n-3 and n-6 polyunsaturated fatty acids (PUFA)-rich diets decrease the acute inflammatory response partially explained by the high corticosterone basal levels. the present study aimed to determine the effect of hyperlipidic diets (PUFA n-3 or n-6) on phagocytosis, hydrogen peroxide (H2O2) and nitric oxide (NO) release by macrophages, bradykinin (BK) and NO release in the paw inflammatory perfusate and Kallikrein (KK), corticosterone and leptin blood levels. Hyperlipidic diets decreased H2O2 release from macrophages stimulated by carrageenan or phorbol-miristate-acetate (PMA), NO release from macrophage stimulated by carrageenan, BK and NO release in the edema perfusate, KK plasma levels and the increase of serum leptin after carrageenan stimulus. These data show that both fish and soybean oil-rich diets promote similar alterations on inflammatory mediators of carrageenan edema and a causal association with the anti-inflammatory effect of these diets.
Keywords Polyunsaturated fatty acids
Inflammation
Corticosterone
Bradykinin
Nitric oxide
Hydrogen peroxide
Leptin
Language English
Date 2005-04-01
Published in Inflammation. New York: Springer/plenum Publishers, v. 29, n. 2-3, p. 81-89, 2005.
ISSN 0360-3997 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 81-89
Origin https://dx.doi.org/10.1007/s10753-006-9002-2
Access rights Closed access
Type Article
Web of Science ID WOS:000240258300003
URI https://repositorio.unifesp.br/handle/11600/28215

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