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dc.contributor.authorBuratini, J.
dc.contributor.authorGlapinski, V. F.
dc.contributor.authorGiometti, I. C.
dc.contributor.authorTeixeira, A. B.
dc.contributor.authorCosta, I. B.
dc.contributor.authorAvellar, MCW
dc.contributor.authorBarros, C. M.
dc.contributor.authorPrice, C. A.
dc.identifier.citationMolecular Reproduction and Development. Hoboken: Wiley-liss, v. 70, n. 3, p. 255-261, 2005.
dc.description.abstractParacrine cell signaling is thought to be important for ovarian follicle development, and a role for some members of the fibroblast growth factor (FGF) family have been suggested. in the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR-3c and FGFR-4) are expressed in bovine preantral follicles. Reverse transcription-polymerase chain reaction was used to amplify bovine FGF-8, FGFR-3c, and FGFR-4 from preantral follicle samples and a variety of fetal and adult tissues. All three genes were widely expressed in fetal tissues, with a restricted expression pattern in adult tissues. FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%). FGFR-3c expression frequency was significantly lower in primordial compared to secondary follicles, and FGF-8 expression showed a similar trend. FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c. We conclude that FGF-8 and its receptors are expressed in preantral follicles in a developmentally regulated manner. (C) 2005 Wiley-Liss, Inc.en
dc.relation.ispartofMolecular Reproduction and Development
dc.rightsAcesso restrito
dc.subjectfibroblast growth factor-8en
dc.subjectfibroblast growth factor receptor-3cen
dc.subjectfibroblast growth factor receptor-4en
dc.subjectpreantral follicleen
dc.titleExpression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral folliclesen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Montreal
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Farmacol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Reprod Anim, Fac Vet Med, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv Montreal, Fac Med Vet, Ctr Rech Reprod Anim, St Hyacinthe, PQ J2S 7C6, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science

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