Expression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles
Glapinski, V. F.
Giometti, I. C.
Teixeira, A. B.
Costa, I. B.
Barros, C. M.
Price, C. A.
É parte deMolecular Reproduction and Development
MetadadoMostrar registro completo
Paracrine cell signaling is thought to be important for ovarian follicle development, and a role for some members of the fibroblast growth factor (FGF) family have been suggested. in the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR-3c and FGFR-4) are expressed in bovine preantral follicles. Reverse transcription-polymerase chain reaction was used to amplify bovine FGF-8, FGFR-3c, and FGFR-4 from preantral follicle samples and a variety of fetal and adult tissues. All three genes were widely expressed in fetal tissues, with a restricted expression pattern in adult tissues. FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%). FGFR-3c expression frequency was significantly lower in primordial compared to secondary follicles, and FGF-8 expression showed a similar trend. FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c. We conclude that FGF-8 and its receptors are expressed in preantral follicles in a developmentally regulated manner. (C) 2005 Wiley-Liss, Inc.
CitaçãoMolecular Reproduction and Development. Hoboken: Wiley-liss, v. 70, n. 3, p. 255-261, 2005.
Palavras-chavefibroblast growth factor-8
fibroblast growth factor receptor-3c
fibroblast growth factor receptor-4
- EPM - Artigos 
Apresentado os itens relacionados pelo título, autor e assunto.
Protein expression of VEGF, IGF-1 and FGF in retroocular connective tissues and clinical correlation in Graves' ophthalmopathy Matos, Kimble [UNIFESP]; Manso, Paulo Gois [UNIFESP]; Marback, Eduardo [UNIFESP]; Furlanetto, Reinaldo [UNIFESP]; Alberti, Gustave Nosé; Nosé, Vania [UNIFESP] (Conselho Brasileiro de Oftalmologia, 2008-08-01)PURPOSE: To investigate the immunohistochemical expression (IGF-1, EGFr, EGF, c-erbB-2/HER-2/neu, PDGF-A, PDGF-B, FGF and VEGF) in patients with Graves' ophthalmopathy. METHODS: Twenty-four samples (Graves' ophthalmopathy ...
Santos, Deny Anderson dos [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2015-07-31)TRACT Anti-angiogenic therapy has already shown its potential and has been approved for the treatment of some tumors when associated with conventional cytotoxic therapies. Among the anti-angiogenic drugs, there are monoclonal ...
Keratinocyte growth factor, tumor necrosis factor-alpha and interleukin-1 beta gene expression in cultured fibroblasts and keratinocytes from burned patients Gragnani, Alfredo [UNIFESP]; Müller, Bruno Rafael [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Noronha, Samuel Marcos Ribeiro de [UNIFESP]; Ferreira, Lydia Masako [UNIFESP] (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2013-08-01)PURPOSE: To evaluate the gene expression of KGF, TNF-alpha and IL-1 beta in skin fibroblasts and keratinocytes cultured from burned patients. METHODS: Three patients with large burns and three patients with small burns, ...