Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats

Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats

Author Andersen, Monica Levy Autor UNIFESP Google Scholar
Martins, Paulo José Forcina Autor UNIFESP Google Scholar
D'Almeida, Vânia Autor UNIFESP Google Scholar
Bignotto, Magda Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Since previous data of our group showed increased concentrations in HPA axis hormones in sleep deprived rats, we hypothesized that this augmentation could produce effects in other hormonal systems, particularly in the sexual system. Considering that little is known about how the hormonal system changes during the recovery period after sleep deprivation (SD), our objective was to examine from what point SD alters sexual and stress-related hormones along with plasma catecholamine concentrations during 4 days. We also sought to verify the time course of their recovery after an equivalent period of recovery sleep. Rats were deprived of sleep by the platform technique for 1-4 days and were allowed to recover for the same period. Plasma catecholamines [dopamine (DA) and noradrenaline (NOR)], testosterone, estrone, progesterone, prolactin, corticosterone and adrenocorticotropic hormone (ACTH) concentrations were measured. Comparisons between groups showed that the SD procedure used in the present study produced marked alterations in almost all studied hormones from 24 h of SD, except for estrone and prolactin (which required 96 h of SD to become altered). Testosterone and estrone decreased, whereas progesterone, prolactin, corticosterone, ACTH, DA and NOR increased. During recovery period, progesterone, prolactin and corticosterone concentrations returned to control levels, whereas testosterone, estrone, NOR and DA did not. in addition, after 48 h of recovery ACTH and NOR decreased below control concentrations, remaining low until 96 h of sleep recovery. Thus, SD showed long lasting, differential effects upon these neurochemicals suggesting that each has its own pattern of responses to SD as well as variable periods of recovery.
Keywords catecholamines
sleep deprivation
Language English
Date 2005-03-01
Published in Journal of Sleep Research. Oxford: Blackwell Publishing Ltd, v. 14, n. 1, p. 83-90, 2005.
ISSN 0962-1105 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing Ltd
Extent 83-90
Origin http://dx.doi.org/10.1111/j.1365-2869.2004.00428.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000227316500012
URI http://repositorio.unifesp.br/handle/11600/28162

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account