Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and F recombinants in São Paulo, Brazil

Date
2005-02-01Author
De Sa, D. J.
Sanabani, S.
Diaz, R. S.
Munerato, P.
Brunstein, A.
Fusuma, E.
Sabino, E. C.
Janini, L. M.
Type
ArtigoISSN
0889-2229Is part of
Aids Research and Human RetrovirusesDOI
10.1089/aid.2005.21.145Metadata
Show full item recordAbstract
Recombination is one of the major mechanisms contributing to human immunodeficiency virus type I (HIV-1) variability. Analysis of pol gene sequences of 215 HIV-1 samples from São Paulo, Brazil classified 189 sequences as subtype B (87.9%), 8 sequences as subtype F (3.7%), and 18 sequences (8.4%) as B/F recombinants. After the analysis of the pol gene, a subset of six recombinant samples composed of sequences with a related recombinant pol structure was selected for full-length genome analysis to identify a possible circulating recombinant form. According to full-length genome analysis, recombination was higher in gag, protease, reverse transcriptase, integrase, and vif. Identification of many distinct recombinant forms and the absence of an identifiable HIV-1 circulating recombinant form suggest that a high frequency of dual infections between HIV-1 subtypes B and F is occurring in São Paulo, Brazil.
Citation
Aids Research and Human Retroviruses. Larchmont: Mary Ann Liebert Inc, v. 21, n. 2, p. 145-151, 2005.Collections
- Em verificação - Geral [7511]