Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and F recombinants in São Paulo, Brazil
De Sa, D. J.
Diaz, R. S.
Sabino, E. C.
Janini, L. M.
Is part ofAids Research and Human Retroviruses
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Recombination is one of the major mechanisms contributing to human immunodeficiency virus type I (HIV-1) variability. Analysis of pol gene sequences of 215 HIV-1 samples from São Paulo, Brazil classified 189 sequences as subtype B (87.9%), 8 sequences as subtype F (3.7%), and 18 sequences (8.4%) as B/F recombinants. After the analysis of the pol gene, a subset of six recombinant samples composed of sequences with a related recombinant pol structure was selected for full-length genome analysis to identify a possible circulating recombinant form. According to full-length genome analysis, recombination was higher in gag, protease, reverse transcriptase, integrase, and vif. Identification of many distinct recombinant forms and the absence of an identifiable HIV-1 circulating recombinant form suggest that a high frequency of dual infections between HIV-1 subtypes B and F is occurring in São Paulo, Brazil.
CitationAids Research and Human Retroviruses. Larchmont: Mary Ann Liebert Inc, v. 21, n. 2, p. 145-151, 2005.
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