Early presence of calcium oxalate deposition in kidney graft biopsies is associated with poor long-term graft survival

Early presence of calcium oxalate deposition in kidney graft biopsies is associated with poor long-term graft survival

Author Pinheiro, Helady Sanders Google Scholar
Camara, Niels Olsen Saraiva Autor UNIFESP Google Scholar
Osaki, Kikumi Suzete Autor UNIFESP Google Scholar
Moura, Luiz Antonio Ribeiro de Autor UNIFESP Google Scholar
Pacheco-Silva, Alvaro Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Juiz de Fora
Abstract Accumulated oxalate will be excreted after renal transplantation, creating an increased risk of tubular precipitation, especially in the presence of allograft dysfunction. We evaluated calcium oxalate (CaOx) deposition in renal allograft biopsies with early dysfunction, its association with acute tubular necrosis (ATN) and graft survival. We studied 97 renal transplant patients, submitted to a graft biopsy within 3 months post-transplant, and reanalyzed them after 10 years. We analyzed renal tissue under polarized light and quantified CaOx deposits. CaOx deposits were detected in 52.6% of the patients; 26.8% were of mild and 25.8% of moderate intensity. the deposits were more frequent in biopsies performed within 3 weeks post-transplant (82.4 vs. 63.0%, p < 0.05) and in allografts with more severe renal dysfunction (creatinine 5.6 mg/dL vs. 3.4 mg/dL, p < 0.001). ATN incidence was also higher in patients with CaOx deposits (47% vs. 24%, p < 0.001). Twelve-year graft survival was strikingly worse in patients with CaOx deposits compared to those free of deposits (49.7 vs. 74.1%, p = 0.013). Our study shows a high incidence of CaOx deposits in kidney allografts with early dysfunction, implying an additional risk for acute tubular injury, with a negative impact on graft survival.
Keywords allograft survival
acute tubular necrosis
calcium oxalate
renal transplantation
Language English
Date 2005-02-01
Published in American Journal of Transplantation. Copenhagen: Blackwell Munksgaard, v. 5, n. 2, p. 323-329, 2005.
ISSN 1600-6135 (Sherpa/Romeo, impact factor)
Publisher Blackwell Munksgaard
Extent 323-329
Origin http://dx.doi.org/10.1111/j.1600-6143.2004.00684.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000226332700017
URI http://repositorio.unifesp.br/handle/11600/28126

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