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dc.contributor.authorCastanheira, Mariana [UNIFESP]
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorMendes, Rodrigo Elisandro [UNIFESP]
dc.contributor.authorJones, R. N.
dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.identifier.citationClinical Microbiology and Infection. Oxford: Blackwell Publishing Ltd, v. 10, n. 7, p. 645-651, 2004.
dc.description.abstractA total of 1561 pneumococcal isolates were collected in 1997-2001, mainly from patients with community-acquired respiratory tract infections, and susceptibilities were tested by reference broth microdilution against 29 antimicrobial agents. in general, 69.3% of strains were considered susceptible (MIC less than or equal to 0.06 mg/L) to penicillin. Resistance to penicillin (MIC greater than or equal to 2 mg/L) and cefotaxime (MIC greater than or equal to 4 mg/L) was found in 11.9% and 0.4% of isolates, respectively. the fluoroquinolones gatifloxacin (MIC90, 0.5 mg/L) and levofloxacin (MIC90, 1 mg/L) were active against > 99% of the isolates tested. Among the other non-beta-lactam drugs tested, the rank order of susceptibility was chloramphenicol (95.6%) > clindamycin (94.5%) > azithromycin (88.5%) > clarithromycin (87.5%) >tetracycline (79.5%) > trimethoprim + sulphamethoxazole (60.5%). the penicillin-non-susceptible isolates presented higher rates of resistance to other antimicrobial agents. the rank order of penicillin resistance rates among the seven participating countries was Mexico (25.0%) > Uruguay (19.2%) > Chile (18.3%) > Colombia = Argentina (9.9%) > Brazil (3.9%) > Venezuela (2.8%). the regional rate of penicillin resistance did not vary significantly over the years studied (p 0.339). Screening for the ermB and mefA genes by multiplex rapid cycle PCR on 23 erythromycin-resistant isolates collected during the year 2001 showed that 43.5% and 56.5%, respectively, were positive for ermB and mefA. Overall, the results indicated that antimicrobial susceptibilities of Streptococcus pneumoniae vary significantly among Latin American countries. Regional and local surveillance programmes are necessary to guide empirical therapy of pneumococcal infection in Latin American countries.en
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofClinical Microbiology and Infection
dc.rightsAcesso aberto
dc.subjectcommunity-acquired pneumoniaen
dc.subjectLatin Americaen
dc.subjectrespiratory tract infectionsen
dc.subjectStreptococcus pneumoniaeen
dc.titleAntimicrobial susceptibility of Streptococcus pneumoniae in Latin America: results from five years of the SENTRY Antimicrobial Surveillance Programen
dc.contributor.institutionJones Grp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationJones Grp, JMI Labs, N Liberty, IA 52317 USA
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Doencas Infecc & Parasitarias, Lab Especial Microbiol Clin, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Doencas Infecc & Parasitarias, Lab Especial Microbiol Clin, São Paulo, Brazil
dc.description.sourceWeb of Science

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