Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity

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dc.contributor.author Martins, PJF
dc.contributor.author D'Almeida, V
dc.contributor.author Pedrazzoli, M.
dc.contributor.author Lin, L.
dc.contributor.author Mignot, E.
dc.contributor.author Tufik, S.
dc.date.accessioned 2016-01-24T12:37:03Z
dc.date.available 2016-01-24T12:37:03Z
dc.date.issued 2004-03-15
dc.identifier http://dx.doi.org/10.1016/j.regpep.2003.10.003
dc.identifier.citation Regulatory Peptides. Amsterdam: Elsevier B.V., v. 117, n. 3, p. 155-158, 2004.
dc.identifier.issn 0167-0115
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27677
dc.description.abstract The hypocretins (orexins) are recently discovered neuropeptides initially associated with feeding behavior and sleep regulation. However, the normal function of these peptides is unclear and a number of studies have reported a role in energy homeostasis and locomotor activity. Exercise (or physical activity) is the most powerful way of challenging the internal homeostatic process. This study examines the circadian differences in response to forced activity and homeostatic challenges on hypocretin-1 (Hcrt-1) levels in the cerebrospinal fluid (CSF) of rats. Hcrt-1 levels were decreased after long-term immobilization at the end of active phase (zeigeber time-0, ZT-0) and increased after short-term forced swimming in the rest phase (ZT-8). Nevertheless, no effects were observed after short-term immobilization, total sleep deprivation or cold exposure. We concluded that despite the relation between hypocretins, stress and sleep regulation reported in the literature, short-term total sleep deprivation, immobilization and cold exposure did not induce increases in CSF Hcrt-1 levels at ZT-0 and ZT-8. On the other hand, the relationship between hypocretinergic system activation and motor activation is reinforced by decrease in Hcr-1 levels after long-term immobilization at ZT-0 and its increased levels after short-term forced swimming at ZT-8 in CSF of rats. (C) 2003 Elsevier B.V. All rights reserved. en
dc.format.extent 155-158
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Regulatory Peptides
dc.rights Acesso restrito
dc.subject sleep deprivation en
dc.subject cold en
dc.subject immobilization en
dc.subject swimming en
dc.subject stress en
dc.subject exercise en
dc.title Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Stanford Univ
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, Sleep Inst, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, BR-04024002 São Paulo, Brazil
dc.description.affiliation Stanford Univ, Sch Med, Ctr Narcolepsy, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, Sleep Inst, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.regpep.2003.10.003
dc.description.source Web of Science
dc.identifier.wos WOS:000188956500001



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