Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

Date
2004-03-01Author
Bressan, R. A.
Jones, H. M.
Pilowsky, L. S.
Type
ArtigoISSN
0269-8811Is part of
Journal of PsychopharmacologyDOI
10.1177/0269881104040251Metadata
Show full item recordAbstract
Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. the case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.
Citation
Journal of Psychopharmacology. London: Sage Publications Ltd, v. 18, n. 1, p. 124-127, 2004.Keywords
antipsychotic agentsatypical antipsychotic drugs
clozapine
dopamine
D-2 receptors
olanzapine
quetiapine
risperidone
tardive dyskinesia
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