Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection

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dc.contributor.author Souza e Silva, Ivonete Sandra de [UNIFESP]
dc.contributor.author Ferraz, MLCG
dc.contributor.author Perez, R. M.
dc.contributor.author Lanzoni, V. P.
dc.contributor.author Figueiredo, V. M.
dc.contributor.author Silva, AEB
dc.date.accessioned 2016-01-24T12:37:02Z
dc.date.available 2016-01-24T12:37:02Z
dc.date.issued 2004-03-01
dc.identifier http://dx.doi.org/10.1111/j.1440-1746.2003.03256.x
dc.identifier.citation Journal of Gastroenterology and Hepatology. Carlton: Blackwell Publishing Asia, v. 19, n. 3, p. 314-318, 2004.
dc.identifier.issn 0815-9319
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27664
dc.description.abstract Background: Increased serum gamma-glutamyl transferase (GGT) levels are frequently observed in chronic hepatitis C virus (HCV) infection. However, the significance of this finding remains unclear. the purpose of the present paper was to assess the relationship between GGT levels and clinical, biochemical and histological features in chronic HCV-infected carriers.Methods: Patients with a liver biopsy presenting anti-HCV and HCV-RNA were evaluated. Age, gender, risk factors of transmission, serum alanine aminotransferase (ALT), GGT and alkaline phosphatase (ALP) levels and histological features were assessed in all. Data were analyzed statistically by the chi(2) test and multivariate logistic regression analysis.Results: Among 201 patients studied, elevated GGT levels and bile duct damage were observed in 48% and 35% of them, respectively. No association was seen between GGT level and bile duct damage or between GGT level and hepatic steatosis. Inititally, age >40 years (P=0.007), elevated ALT (P=0.01), grading of inflammatory activity (P=0.004) and staging of fibrosis (P<0.001) were found to be associated with elevated GGT levels. After multivariate regression analysis, histology grading 3 and 4 inflammation activity (P=0.01) and staging 3 and 4 fibrosis (P=0.01) remained independently associated with elevated GGT level.Conclusions: A significant number of patients with chronic HCV infection had elevated serum GGT levels. Furthermore, this enzyme seemed to be useful as an indirect marker of more advanced liver disease in chronic hepatitis C. (C) 2004 Blackwell Publishing Asia Pty Ltd. en
dc.format.extent 314-318
dc.language.iso eng
dc.publisher Blackwell Publishing Asia
dc.relation.ispartof Journal of Gastroenterology and Hepatology
dc.rights Acesso restrito
dc.subject chronic infection en
dc.subject cirrhosis en
dc.subject gamma-glutamyl transferase en
dc.subject hepatitis C en
dc.subject liver disease en
dc.title Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Gastroenterol, Escola Paulista Med São Paulo, Dept Gastroenterol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, Escola Paulista Med São Paulo, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Gastroenterol, Escola Paulista Med São Paulo, Dept Gastroenterol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, Escola Paulista Med São Paulo, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1111/j.1440-1746.2003.03256.x
dc.description.source Web of Science
dc.identifier.wos WOS:000188506000011



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