Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection

Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection

Author Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Ferraz, MLCG Google Scholar
Perez, R. M. Google Scholar
Lanzoni, V. P. Google Scholar
Figueiredo, V. M. Google Scholar
Silva, AEB Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Increased serum gamma-glutamyl transferase (GGT) levels are frequently observed in chronic hepatitis C virus (HCV) infection. However, the significance of this finding remains unclear. the purpose of the present paper was to assess the relationship between GGT levels and clinical, biochemical and histological features in chronic HCV-infected carriers.Methods: Patients with a liver biopsy presenting anti-HCV and HCV-RNA were evaluated. Age, gender, risk factors of transmission, serum alanine aminotransferase (ALT), GGT and alkaline phosphatase (ALP) levels and histological features were assessed in all. Data were analyzed statistically by the chi(2) test and multivariate logistic regression analysis.Results: Among 201 patients studied, elevated GGT levels and bile duct damage were observed in 48% and 35% of them, respectively. No association was seen between GGT level and bile duct damage or between GGT level and hepatic steatosis. Inititally, age >40 years (P=0.007), elevated ALT (P=0.01), grading of inflammatory activity (P=0.004) and staging of fibrosis (P<0.001) were found to be associated with elevated GGT levels. After multivariate regression analysis, histology grading 3 and 4 inflammation activity (P=0.01) and staging 3 and 4 fibrosis (P=0.01) remained independently associated with elevated GGT level.Conclusions: A significant number of patients with chronic HCV infection had elevated serum GGT levels. Furthermore, this enzyme seemed to be useful as an indirect marker of more advanced liver disease in chronic hepatitis C. (C) 2004 Blackwell Publishing Asia Pty Ltd.
Keywords chronic infection
gamma-glutamyl transferase
hepatitis C
liver disease
Language English
Date 2004-03-01
Published in Journal of Gastroenterology and Hepatology. Carlton: Blackwell Publishing Asia, v. 19, n. 3, p. 314-318, 2004.
ISSN 0815-9319 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing Asia
Extent 314-318
Access rights Closed access
Type Article
Web of Science ID WOS:000188506000011

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