The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray

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dc.contributor.author Borra, R. C.
dc.contributor.author Andrade, P. M.
dc.contributor.author Silva, IDCG
dc.contributor.author Morgun, A.
dc.contributor.author Weckx, LLM
dc.contributor.author Smirnova, A. S.
dc.contributor.author Franco, M.
dc.date.accessioned 2016-01-24T12:37:02Z
dc.date.available 2016-01-24T12:37:02Z
dc.date.issued 2004-03-01
dc.identifier http://dx.doi.org/10.1111/j.0904-2512.2004.00089.x
dc.identifier.citation Journal of Oral Pathology & Medicine. Copenhagen: Blackwell Munksgaard, v. 33, n. 3, p. 140-146, 2004.
dc.identifier.issn 0904-2512
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27663
dc.description.abstract BACKGROUND: the reduced ability to activate oral tolerance plays a role in the pathogenesis of some gastrointestinal inflammatory diseases. This activation may reflect a preferential reduction of a T-helper (Th)2- or Th3-type response. in recurrent aphthous ulceration (RAU), genetic and environmental factors may contribute to low tolerance, permitting a cytotoxic reaction against the oral epithelium. the cytokine profile has not permitted the definition of RAU as resulting from enhanced Th1 or Th2 responses. A cDNA microarray study would allow the identification of differentially expressed genes and provide a basis for classification of the immune response.METHODS: the cDNA from 29 samples of aphthae and from 11 samples of normal mucosa from aphthae-free volunteers were hybridized on microarray membranes with 1176 genes.RESULTS: Forty-one differentially expressed genes were identified, and a higher expression level of the Th1 gene cluster in RAU was found.CONCLUSIONS: Microarrays permitted us definition of the gene expression profile of the lesion and identify an increased Th1 activity in RAU lesions. en
dc.format.extent 140-146
dc.language.iso eng
dc.publisher Blackwell Munksgaard
dc.relation.ispartof Journal of Oral Pathology & Medicine
dc.rights Acesso restrito
dc.subject aphthae en
dc.subject cDNA microarray en
dc.subject gene expression analysis en
dc.subject oral tolerance en
dc.subject Th1/Th2 en
dc.subject RAU en
dc.title The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Mol Gynecol Lab, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Clin Immunol Lab, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Otolaryngol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Mol Gynecol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Clin Immunol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Otolaryngol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.0904-2512.2004.00089.x
dc.description.source Web of Science
dc.identifier.wos WOS:000188825400003



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