The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray

The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray

Author Borra, R. C. Google Scholar
Andrade, P. M. Google Scholar
Silva, IDCG Google Scholar
Morgun, A. Google Scholar
Weckx, LLM Google Scholar
Smirnova, A. S. Google Scholar
Franco, M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract BACKGROUND: the reduced ability to activate oral tolerance plays a role in the pathogenesis of some gastrointestinal inflammatory diseases. This activation may reflect a preferential reduction of a T-helper (Th)2- or Th3-type response. in recurrent aphthous ulceration (RAU), genetic and environmental factors may contribute to low tolerance, permitting a cytotoxic reaction against the oral epithelium. the cytokine profile has not permitted the definition of RAU as resulting from enhanced Th1 or Th2 responses. A cDNA microarray study would allow the identification of differentially expressed genes and provide a basis for classification of the immune response.METHODS: the cDNA from 29 samples of aphthae and from 11 samples of normal mucosa from aphthae-free volunteers were hybridized on microarray membranes with 1176 genes.RESULTS: Forty-one differentially expressed genes were identified, and a higher expression level of the Th1 gene cluster in RAU was found.CONCLUSIONS: Microarrays permitted us definition of the gene expression profile of the lesion and identify an increased Th1 activity in RAU lesions.
Keywords aphthae
cDNA microarray
gene expression analysis
oral tolerance
Language English
Date 2004-03-01
Published in Journal of Oral Pathology & Medicine. Copenhagen: Blackwell Munksgaard, v. 33, n. 3, p. 140-146, 2004.
ISSN 0904-2512 (Sherpa/Romeo, impact factor)
Publisher Blackwell Munksgaard
Extent 140-146
Access rights Closed access
Type Article
Web of Science ID WOS:000188825400003

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