Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats
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2004-03-01
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Perry, J. C.
Vital, MABF
Frussa-Filho, R.
Tufik, S.
Palermo-Neto, J.
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In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. the animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. the results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1). in haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal. (C) 2003 Elsevier B.V./ECNP. All rights reserved.
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European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 14, n. 2, p. 127-133, 2004.