Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

Author Pedrazzoli, M. Google Scholar
D'Almeida, V Google Scholar
Martins, PJF Google Scholar
Machado, R. B. Google Scholar
Ling, L. Google Scholar
Nishino, S. Google Scholar
Tufik, S. Google Scholar
Mignot, E. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract Rat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 It of REM sleep deprivation and following 24 It of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 It of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity. (C) 2003 Elsevier B.V All rights reserved.
Keywords hypocretin-1
cerebrospinal fluid
REM sleep
Language English
Date 2004-01-02
Published in Brain Research. Amsterdam: Elsevier B.V., v. 995, n. 1, p. 1-6, 2004.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1-6
Origin http://dx.doi.org/10.1016/j.brainres.2003.09.032
Access rights Closed access
Type Article
Web of Science ID WOS:000187747400001
URI http://repositorio.unifesp.br/handle/11600/27581

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