Show simple item record

dc.contributor.authorFenelon, G.
dc.contributor.authorFranco, M.
dc.contributor.authorMora, O.
dc.contributor.authorKatchburian, E.
dc.contributor.authorPaola, AAV de
dc.date.accessioned2016-01-24T12:34:14Z
dc.date.available2016-01-24T12:34:14Z
dc.date.issued2004-01-01
dc.identifierhttp://dx.doi.org/10.1111/j.1540-8159.2004.00387.x
dc.identifier.citationPace-pacing and Clinical Electrophysiology. Malden: Blackwell Futura Publishing, Inc, v. 27, n. 1, p. 65-72, 2004.
dc.identifier.issn0147-8389
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27567
dc.description.abstractWe evaluated the effects of combined therapy with anti-inflammatory and antioxidant drugs on the healing of radiofrequency (RF) lesions (70degreesC, 60 s) produced in the right atrium and each ventricle of 21 adult dogs. Three groups were studied: acute (n = 7, sacrificed 1 hour after RF); control (n = 7, sacrificed 54 +/- 29 days after RF); and dogs (n = 7, sacrificed 32 +/- 5 days after RF) receiving combined therapy with allopurinol (400 mg po 24 and 2 hours before RF); verapamil (200 mug/kg IV 15 min before and after RF); hydrocortisone (10 mg/kg IV after RF) and prednisone (20 mg po for 29 days). Atrial (n = 37) and ventricular (n = 70) lesion dimensions were determined and 21 right ventricular apex lesions (1 per dog) were selected for light and electron microscopy analysis. Histological and ultrastructural (US) characteristics in three zones extending from the visible lesion border, A (0-3 mm); B (3-6 mm); and C (6-9 mm), were assessed. in chronic groups, atrial and ventricular lesion dimensions were similar, but delayed scar formation was noted in treated animals. Acutely and at follow-up, significant US abnormalities occurred in zones A and B and chronic lesions exhibited type I collagen proliferation. in Zone A, the extent of US injury and collagen proliferation was significantly less in treated dogs. Further, Zone B was normal in 5/7 (71%) treated dogs and in 0/7 (0%) controls. Zone C was essentially normal in all groups. Combined therapy with steroids, verapamil, and allopurinol is effective in limiting US damage surrounding chronic RF lesions.en
dc.format.extent65-72
dc.language.isoeng
dc.publisherBlackwell Futura Publishing, Inc
dc.relation.ispartofPace-pacing and Clinical Electrophysiology
dc.rightsAcesso restrito
dc.subjectarrhythmiasen
dc.subjectelectrophysiologyen
dc.subjectradiofrequency ablationen
dc.titleCombined therapy with steroids and antioxidants prevents ultrastructural damage surrounding chronic radiofrequency lesionsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Dept Cardiol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Dept Morphol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Dept Cardiol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Dept Morphol, BR-04039032 São Paulo, Brazil
dc.identifier.doi10.1111/j.1540-8159.2004.00387.x
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000188653100011


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record