The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

Dale, C. S.; Goncalves, LRC; Juliano, L.; Juliano, M. A.; Silva, AMM da; Giorgi, R.

Date

2004-01-01

Author

Dale, C. S.

Goncalves, LRC

Juliano, L.

Juliano, M. A.

Silva, AMM da

Giorgi, R.

Type

Artigo

ISSN

0196-9781

Is part of

Peptides

DOI

10.1016/j.peptides.2003.12.008

Metadata

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Abstract

The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.

Citation

Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.