Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation

Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation

Author Achar, Eduardo Autor UNIFESP Google Scholar
Achar, Rosi Aparecida Nunes Autor UNIFESP Google Scholar
Paiva, Therezinha Bandiera Autor UNIFESP Google Scholar
Campos, Alexandre Holthausen Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Sao Teodoro Vet Hosp
Abstract Background. We investigated the effects of amitriptyline in the urinary tract smooth muscle and urolithiasis.Methods. Cats presenting with obstructive acute renal failure (ARF) received amitriptyline, and renal function and survival rates were analyzed. Isometric contractions and membrane potentials of rat, pig, or human isolated urinary tract smooth muscle were recorded in the presence or absence of amitriptyline.Results. Twenty cats with obstructive ARF caused by urethral plugs received amitriptyline. in all cases, plugs were completely eliminated, and renal function returned to normal, with a 100% survival rate in the follow-up. Amitriptyline produced potent relaxations in rat urethral strips, accompanied by significant reductions in urethral ring membrane potential. This effect was prevented by pretreatment of urethral rings with 4-aminopyridine (4-AP), a voltage-dependent potassium channel blocker. Amitriptyline abolished in a reversible manner acetylcholine-, bradykinin-, and KCl-induced contractions in rat isolated bladder, and this effect was also prevented by 4-AP. of interest, spontaneous and KCl-induced contractions of pig and human isolated ureter were also blocked by amitriptyline.Conclusion. Our results indicate that amitriptyline is an effective and potent relaxant of urinary tract smooth muscle and this effect is mediated by opening of voltage dependent-potassium channels. We suggest that amitriptyline administration may help to promote elimination of urinary calculi.
Keywords amitriptyline
urinary tract smooth muscle
voltage-dependent potassium channel
obstructive acute renal failure
Language English
Date 2003-10-01
Published in Kidney International. Malden: Blackwell Publishing Inc, v. 64, n. 4, p. 1356-1364, 2003.
ISSN 0085-2538 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing Inc
Extent 1356-1364
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000185226200024

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