Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats

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2003-08-01
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Hirata, A. E.
Alvarez-Rojas, F.
Carvalheira, JBC
Carvalho, CRD
Dolnikoff, M. S.
Saad, MJA
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PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. in 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance. (C) 2003 Elsevier Science Inc. All rights reserved.
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Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 73, n. 11, p. 1369-1381, 2003.
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