Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats

Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats

Author Hirata, A. E. Google Scholar
Alvarez-Rojas, F. Google Scholar
Carvalheira, JBC Google Scholar
Carvalho, CRD Google Scholar
Dolnikoff, M. S. Google Scholar
Saad, MJA Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. in 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance. (C) 2003 Elsevier Science Inc. All rights reserved.
Keywords insulin
PTP1B
MSG
adiposity
Language English
Date 2003-08-01
Published in Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 73, n. 11, p. 1369-1381, 2003.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1369-1381
Origin http://dx.doi.org/10.1016/S0024-3205(03)00477-6
Access rights Closed access
Type Article
Web of Science ID WOS:000184236800002
URI http://repositorio.unifesp.br/handle/11600/27347

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