Cardiovascular responses to substance P in the nucleus tractus solitarii: microinjection study in conscious rats

Cardiovascular responses to substance P in the nucleus tractus solitarii: microinjection study in conscious rats

Author Abdala, Ana Paula Lima Autor UNIFESP Google Scholar
Haibara, A. S. Google Scholar
Colombari, Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Abstract The cardiovascular effects of substance P (SP) microinjections in the nucleus tractus solitarii (NTS) were evaluated in conscious rats. We chose this model because it is an effective way to access some of the cardiovascular effects of neurotransmitters in the NTS without the inconvenience of blunting pathways with anesthetic agents or removing forebrain projections by decerebration. the cardiovascular responses to SP injections were also evaluated after chronic nodose ganglionectomy. We found that, in conscious rats, SP microinjections into the NTS induced hypertension and tachycardia. Unilateral and bilateral SP injections into the NTS caused a slow increase in blood pressure and heart rate that peaked 1.5-5 min after injection and lasted for 20-30 min. Nodose ganglionectomy increased the duration of the pressor and tachycardic effects of SP and enhanced the pressor response. These data show that SP in the NTS is involved in pressor pathways. the supersensitivity to SP seen after nodose ganglionectomy suggests that vagal afferent projections are involved in those pressor pathways activated by SP in the NTS.
Keywords blood pressure
heart rate
neurokinins
brain stem
Language English
Date 2003-08-01
Published in American Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 285, n. 2, p. H891-H898, 2003.
ISSN 0363-6135 (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent H891-H898
Origin http://dx.doi.org/10.1152/ajpheart.00869.2002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000184153100052
URI http://repositorio.unifesp.br/handle/11600/27339

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